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Tous les articles retenus par le juge de pertinence, classés par pertinence scientifique
We previously found that soluble pathogenic tau aggregates (tau oligomers) enter brain microvascular endothelial cells and induce cellular senescence and microvascular dysfunction in a tauopathy mouse model. This study shows that soluble pa…
Background: Common side effects of dopamine replacement therapy (DRT) for Parkinson's Disease (PD) are addiction-like impulse control disorders, including compulsive gambling. Gambling products such as slot machines prominently feature rewa…
Reinforcement learning (RL) models describe how reward computations shape our choices, but whether the same computations also shape memory in the human brain is unclear. To address this question, we combined multi-areal intracranial recordi…
Learning novel behaviors requires balancing previously learned actions with the ability to flexibly adapt to changing reward contingencies. This trade-off is well documented in the division of labor between dorsolateral striatum (DLS), whic…
Denali Therapeutics Inc. DNL-921 ATV:Abeta DNA/RNA-based Amyloid-Related Phase 1 started recruiting in August 2026. A single- and multiple-ascending-dose safety study, it is enrolling healthy adults for six weeks of treatment, and people wi…
Denali Therapeutics Inc. DNL-628 OVT:MAPT DNA/RNA-based Tau Phase 1 began in January 2026. The first-in-human study plans to enroll 68 people with early Alzheimer’s disease to receive multiple ascending doses of DNL628, or placebo, by intra…
Background It is common for the elderly population to have age-associated cognitive decline and/or develop neurodegenerative diseases such as dementia. Several studies have suggested that classification algorithms based on linguistic featur…
Abstract Alzheimer’s disease is a prototypical neurodegenerative disease of ageing. Language disorders are part of the clinical picture of Alzheimer’s disease but are most often associated with other cognitive disorders that are responsible…
I've been meaning to point out this Nature Reviews Neuroscience Perspectives article by Barrett and Miller (the same Miller referenced in the previous post). I pass on just the abstract and initial paragraphs of their model. The artic…
arXiv:2609.10890v1 Announce Type: cross Abstract: Parkinson's disease is clinically and biologically heterogeneous, yet its spatiotemporal progression remains poorly characterized. We present a connectome-constrained disease progression mod…
arXiv:2609.10947v1 Announce Type: new Abstract: We propose the Platonic brain bridge hypothesis: omni models, which process video, audio and text jointly like the brain, converge on brain-like representations, and the correspondence is bidi…
Conditions : PARKINSON DISEASE (Disorder) Interventions : Other: Parkinson Neuropsychometric Dementia Assessment Sponsors : Acibadem University Not yet recruiting
BackgroundParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Although MAFF may be involved in PD, the mechanisms underlying this association remain unclear. This study aimed to investigate the potential mechan…
In vivo calcium imaging is a powerful technique for the monitoring activity of large neuronal populations in the intact brain. Two-photon microscopy provides subcellular resolution in head-fixed animals, and miniaturized fluorescence micros…
Imaging neural fluorescence dynamics during unconstrained behavior remains a major challenge in neuroscience. Head-mounted miniature one-photon microscopes enable in vivo recordings from freely behaving animals. Still, their power and data…
Neuroinflammation strongly contributes to the pathogenesis of neurological and neurodegenerative diseases, including Parkinson's disease. We show that ablation of Usp15 in astrocytes and in microglia protects against lethal neuroinflammatio…
Alzheimer's disease (AD) involves progressive neurodegeneration, amyloid-{beta} (A{beta}) pathology and chronic neuroinflammation. Elevated ceramides, generated via neutral sphingomyelinase (nSMase)-mediated sphingomyelin hydrolysis or seri…
Mitochondrial dysfunction and fragmentation in neurons are characteristics of many neurodegenerative conditions. AMP-activated protein kinase (AMPK) is a cellular energy sensor which is hyperactivated in Alzheimers disease. Under stress con…
Despite large-scale recordings, neuroscience has identified representations for only a small fraction of visual features distinguishable by humans. This is increasingly attributed to mixed selectivity, where individual neurons respond to mu…
Structural studies of amyloid fibrils extracted from brain tissue have identified disease-specific fibril polymorphs. However, the mechanisms driving distinct polymorphs remain unclear because no method currently links the cellular context,…
Anti-amyloid {beta} (A{beta}) immunotherapy improves cognitive outcomes in Alzheimer's disease (AD) but is associated with amyloid-related imaging abnormalities (ARIA), through poorly understood mechanisms. To define how anti-A{beta} antibo…
INTRODUCTION: Cognitive decline in Parkinsons disease (PD) may reflect interacting neurodegenerative and cerebrovascular processes, but their distinct temporal contributions remain unclear. METHODS: Newly diagnosed, untreated PD participant…
INTRODUCTION: Individuals with Alzheimer's disease (AD) exhibit substantial heterogeneity in the severity of vascular changes and neurodegeneration, making the identification of biologically meaningful subtypes across the AD spectrum critic…
Background: Anti-amyloid-{beta} (A{beta}) monoclonal antibodies are disease-modifying treatments for early Alzheimer's disease but are associated with amyloid-related imaging abnormalities (ARIA) and intracranial hemorrhage (ICH). However,…
Background: GBA1 variants are common risk factors for Parkinson's disease (PD), yet the structural consequences of most variants remain uncharacterized. No centralized resource currently integrates the growing number of GCase structures, co…
Background: Tuberous sclerosis complex (TSC) is a rare autosomal dominant neurodevelopmental disorder caused by loss-of-function mutations in TSC1 or TSC2, resulting in chronic hyperactivation of the mechanistic target of rapamycin (mTOR) p…
Adaptive decision-making in dynamic environments requires flexible adjustment of learning speed to balance stability and flexibility. When outcomes are highly stochastic, learners must avoid over-interpreting noise and update more slowly, w…
Complement and the Brain: Talks on the Immune System in Neurodegeneration DEMENTIA RESEARCHER Dementia Researcher Five talks from the Complement and the Brain satellite symposium at EMCHD 2026 in Cardiff, on complement in Alzheimer's, strok…
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory impairment, and oxidative stress. Aim: This study investigated the neuroprotective effects of the butanol fraction o…
When doctors are trying to figure out whether Alzheimer’s is the right diagnosis for an individual with cognitive impairment, they turn to biomarker testing to detect the disease’s hallmark proteins in the blood, cerebrospinal fluid, and br…
Conditions : Cognitive Abnormality Interventions : Other: Shared decision-making support tool Sponsors : University of Wisconsin, Madison; National Institute on Aging (NIA) Not yet recruiting
Conditions : Dementia Disorders; Mild Cognitive Impairment (MCI) Sponsors : Assiut University Not yet recruiting
Conditions : Parkinson Disease (PD) Interventions : Other: cognitive rehabilitation program Sponsors : University Hospital, Clermont-Ferrand Not yet recruiting
arXiv:2607.05654v2 Announce Type: replace Abstract: With major advances in cerebral imaging techniques, a large amount of data is available for studying the aging and demented brain. In this contribution, we apply the OASIS-3 dataset to ide…
PubMed Central · auteur h-index 3 · 0 citation
Alzheimer's disease (AD) is the leading cause of dementia in the aging population, with the {varepsilon}4 allele of apolipoprotein E (APOE) being the strongest genetic risk factor. Although astrocytes are a major source of APOE, how APOE al…
One of the most puzzling aspects of perception is postdiction: later information can change how a previous stimulus is perceived [1,2]. This indicates that perception is not a livestream of the external world, but rather a post-hoc reconstr…
Much of our mechanistic understanding of cortical development and neurodevelopmental disorders comes from studies in mice, yet translating these insights to humans rests on a fundamental assumption: that the cortex is organized according to…
Genome maintenance is usually treated as cell-intrinsic, yet brain cells age within multicellular neighborhoods. Whether a cell's DNA damage response (DDR) state is systematically embedded in native tissue architecture is unknown. We used M…
Finger tapping is a crucial clinical window into the brain's motor integrity, particularly in Parkinson's disease (PD). Beyond mere rhythmicity, healthy motor output exhibits long-range correlations (LRCs)--a hallmark of temporal complexity…
Despite decades of extensive research, the complex architecture underlying human brain signaling remains incompletely understood. Previous work investigating the relationship between brain glucose metabolism and functional connectivity (FC)…