Tous les articles retenus par le juge de pertinence, classés par pertinence scientifique
Miller et al. suggest that brain synapses store representations while large-scale rhythmic electric fields dynamically select, route and combine them. Traveling alpha and beta waves could act as movable “stencils” controll…
Molecular staging of Alzheimer's disease (AD) increasingly defines transition boundaries along single-cell pseudo-progression trajectories, yet whether such boundaries reproduce across brain regions, cohorts and molecular modalities is rare…
Circadian disruption, notably sleep disturbances, serves as an early indicator of Alzheimers disease (AD), preceding cognitive symptoms like memory loss. The suprachiasmatic nucleus (SCN) governs biological rhythms and receives direct retin…
Allostatic Structural Realism (ASR 4.1): A Formal Theory of Phenomenal Consciousness. This project presents Allostatic Structural Realism (ASR 4.1), a formal physicalist framework that defines phenomenal consciousness as the precision-weigh…
OSF Preprints (OSF Preprints) · auteur h-index 0 · 0 citation
Multivalent Tau-Fyn interactions cooperatively arrest postsynaptic density condensate dynamics. Abstract Tau-Fyn signaling at postsynaptic sites is implicated in synaptic dysfunction and neuronal hyperexcitability in Alzheimer’s disease and…
bioRxiv (Cold Spring Harbor Laboratory) · auteur h-index 91 · 0 citation
Repurposing apremilast for alzheimer’s disease: multitarget modulation of cAMP‑PI3K/Akt–GSK‑3β and NF‑κB signaling
Metabolic Brain Disease · auteur h-index 16 · 0 citation
Towards a neurophysiological diagnostic marker of Alzheimer's disease using transcranial magnetic stimulation combined with electroencephalography. Background A scalable, objective measure of cortical function that differentiates Alzheimer'…
Journal of Alzheimer s Disease · auteur h-index 64 · 0 citation
Theory of Experiential Degradation: A Metaphysical Narrative Framework of Dimensional Phase Transition and Consciousness . Building on the core presupposition of the Universal Causality-Spacetime PrimordialOntology (UCPO), this paper constr…
Figshare · auteur h-index 0 · 0 citation
Phase separation and protein aggregation in neurodegenerative diseases. Neurodegenerative diseases such as Alzheimer's, Parkinson's, frontotemporal dementia, and ALS are characterized by amyloid protein aggregation involving intrinsically d…
Biophysical Chemistry · auteur h-index 36 · 0 citation
Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the MAPT -S305N model of frontotemporal dementia. ABSTRACT Progressive and chronic neuroinflammation is assoc…
bioRxiv (Cold Spring Harbor Laboratory) · auteur h-index 33 · 0 citation
Association of probiotic medication use with incident Parkinson disease and alzheimer disease: a nationwide nested case–control study
Journal of Neurology · auteur h-index 36 · 0 citation
Timosaponin B-II attenuates hemorrhagic transformation-driven acceleration of alzheimer disease-related pathology after ischemic stroke. Hemorrhagic transformation (HT) is a major complication of reperfusion therapy after ischemic stroke, b…
Biochemistry and Biophysics Reports · auteur h-index 3 · 0 citation
Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios. The genetic architecture of sporadic Early-Onset Alzheimer Disease (sEOAD, onset ≤65 years) remains largely unknown. To assess the de novo mutation (DNM) hypoth…
Molecular Psychiatry · auteur h-index 103 · 0 citation
Speculations About the Nature and Development of Metacognition
auteur h-index 70 · 904 citations
Pharmacological, Non-Pharmacological, and Emerging Therapies for Other Neurodegenerative Diseases. Neurodegenerative diseases such as Alzheimer&s;s disease (AD), Parkinson&s;s disease (PD), and Huntington&s;s disease (HD) are increasing in…
Neurodegenerative Diseases · auteur h-index 16 · 0 citation
Neural Correlates of Consciousness: An Umbrella Review (v7.0). High-rigor Scientific Umbrella Review (v7.0) for Neural Correlates of Consciousness: An Umbrella Review (v7.0)
Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation
Dementia. Progressive cognitive deterioration is a hallmark of the neurodegenerative disorder that is known as dementia. The underlying processes of dementia differ, although they often involve neuroinflammation, vascular alterations, and t…
auteur h-index 2 · 0 citation
The DIME Architecture: A Unified Operational Algorithm for Neural Representation, Dynamics, Control and Integration. Modern neuroscience has accumulated extensive evidence on perception, memory, prediction, valuation, and consciousness, yet…
arXiv (Cornell University) · auteur h-index 14 · 0 citation
From Integrated Information and Global Workspaces to Prior Awareness. Abstract Western frameworks such as Integrated Information Theory (IIT) and Global Workspace Theory (GWT) providerigorous accounts of how experiential contents are integr…
Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation
Consciousness Mechanics (CM) and the Consciousness Component Model (CCM): A Biology-First Control Architecture for Conscious Systems. Consciousness research spans phenomenological accounts, access/global workspace models (Baars, 1988; Dehae…
Open MIND · auteur h-index 0 · 0 citation
Molecular and Microstructural MRI of Neuroinflammation in Alzheimer's Disease. INTRODUCTION: Alzheimer's disease (AD) is a leading cause of cognitive decline in older adults, often diagnosed late when pathology and symptoms are established,…
Current Alzheimer Research · auteur h-index 32 · 0 citation
Background This study aimed at investigating whether high plasma homocysteine (Hcy) levels affect specific cognitive functions in individuals with Frontotemporal Dementia (FTD). While Hcy is a well-established risk factor for cerebrovascula…
Neurological Sciences · auteur h-index 65 · 0 citation
The Storm Behind the Silence: Detecting Cerebral Amyloid Angiopathy-Related Inflammation in a Patient with Dementia. Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare, treatable inflammatory variant of cerebral amyloid ang…
Journal of Brown Hospital Medicine · auteur h-index 16 · 0 citation
Abstract INTRODUCTION Overlaps in symptom presentation limits the capacity to predict functional impairment and future care needs in younger‐onset dementia syndromes. METHODS A general additive model (GAM) was applied to cross‐sectional ret…
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · auteur h-index 36 · 1 citation
An Umbrella Systematic Literature Review to aid the development of a Combined Physical and Psychological Programme for the management of Chronic Traumatic Encephalopathy
Research Square · auteur h-index 11 · 0 citation
Memory and metamemory performance in individuals with and without post-COVID-19 subjective cognitive symptoms. Background Metamemory is the awareness of and ability to evaluate one’s own cognitive abilities. This study examined impaired met…
Journal of Clinical and Experimental Neuropsychology · auteur h-index 82 · 0 citation
Metamemory Functioning in People With Dementia in the Brazilian Context. INTRODUCTION: Metamemory is the ability to monitor and control one's own memory. The objective of our study was to investigate the estimated and actual performance of…
Alzheimer Disease & Associated Disorders · auteur h-index 27 · 0 citation
Social Metamemory Judgments in the Legal Context: Examining Judgments About the Memory of Others. Jurors and other legal decision-makers are often required to make judgments about the likely memory accuracy of another person. Legal systems…
Behavioral Sciences · auteur h-index 39 · 0 citation
The disconnect between metamemory and memory for emotional images. Emotional information is reliably predicted to be remembered better than neutral information, and this has been found for words, images, and facial expressions. However, man…
Cognition & Emotion · auteur h-index 21 · 0 citation
Metamemory: An update of critical findings
Elsevier eBooks · auteur h-index 64 · 1 citation
Intentional binding coincides with explicit sense of agency
Consciousness and Cognition · auteur h-index 28 · 128 citations
A free-energy principle has been proposed recently that accounts for action, perception and learning. This Review looks at some key brain theories in the biological (for example, neural Darwinism) and physical (for example, information theo…
Nature reviews. Neuroscience · auteur h-index 262 · 8007 citations
Chronicles-OCR: A Cross-Temporal Perception Benchmark for the Evolutionary Trajectory of Chinese Characters. Vision Large Language Models (VLLMs) have achieved remarkable success in modern text-rich visual understanding. However, their perc…
arXiv (Cornell University) · auteur h-index 2 · 0 citation
Neural Correlates of Consciousness: A Comprehensive Umbrella Review and Theoretical Integration [SCIENTIFIC V7.0 - Q1 HIGH-IMPACT]. A high-impact systematic synthesis (6+ pages) of meta-analyses regarding Neural Correlates of Consciousness.…
Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation
Hippocampal Amyloid‐Beta And Tau Distributions Differentially Affect Cognition In Centenarians. BACKGROUND: The hippocampus is differentially affected in Alzheimer's disease neuropathologic change (ADNC) versus primary age-related tauopathy…
Alzheimer s & Dementia · auteur h-index 72 · 0 citation
Neural-Mechanical-Force Model: A Multi-Phase Energy Framework Bridging Conscious Intention, Neural Delay, and Biomechanical Output. This study introduces the Neural-Mechanical-Force (NMF) Model, a multidisciplinary framework connecting neur…
OSF Preprints (OSF Preprints) · 0 citation
Preclinical Development of a Vectorized Artificial miRNA Gene Therapy for Tauopathies. Tauopathies, including Alzheimer's disease, are neurodegenerative disorders characterized by the accumulation of microtubule-associated protein tau, whic…
bioRxiv (Cold Spring Harbor Laboratory) · auteur h-index 19 · 2 citations
Consciousness is mostly studied as if it were composed of independent snapshots, aggregating reports over trials and experimental contexts, disregarding any temporal aspect. However, almost nothing is known about how conscious experience sp…
Background: The blood-brain barrier (BBB) is increasingly recognized as an active immunoregulatory interface that responds dynamically to systemic inflammation. As intestinal inflammation can influence brain homeostasis through the gut-brai…
arXiv:2511.01732v3 Announce Type: replace-cross Abstract: We introduce a framework combining geometric modeling with disease progression analysis to investigate tau deposition in Alzheimer's disease (AD) using positron emission tomography (…
arXiv (Cornell University) · auteur h-index 22 · 0 citation