Tous les articles suivis par Vigie Sciences, classés par pertinence scientifique
Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity. Importance: Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer…
JAMA · auteur h-index 214 · 51 citations
γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)
The Lancet Neurology · auteur h-index 204 · 33 citations
Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease. OBJECTIVES: Higher-educated patients with Alzheimer disease (AD) can harbor greater neuropathologic burden…
Neurology · auteur h-index 180 · 23 citations
A brief history of “Alzheimer disease”. The field of Alzheimer disease (AD) has a nosologic problem: The diagnostic label "Alzheimer disease" has several distinctive meanings. The term probable AD was introduced in 1984 to designate a clini…
Neurology · auteur h-index 207 · 100 citations
Scam Awareness Related to Incident Alzheimer Dementia and Mild Cognitive Impairment. Background: Decreased scam awareness may be an early indicator of impending Alzheimer dementia and its precursor, mild cognitive impairment, but prior stud…
Annals of Internal Medicine · auteur h-index 199 · 85 citations
Anosognosia predicts default mode network hypometabolism and clinical progression to dementia. ObjectiveTo identify the pathophysiologic mechanisms and clinical significance of anosognosia for cognitive decline in mild cognitive impairment.…
Neurology · auteur h-index 258 · 85 citations
Memory self-awareness in the preclinical and prodromal stages of Alzheimer’s disease
Neuropsychologia · auteur h-index 172 · 109 citations
Can we model a cognitive footprint of interventions and policies to help to meet the global challenge of dementia?
The Lancet · auteur h-index 135 · 32 citations
Low Cognitive Awareness, but Not Complaint, is a Good Marker of Preclinical Alzheimer's Disease.. BACKGROUND: Subjective cognitive decline (SCD) may result from many conditions, including Alzheimer's disease (AD). OBJECTIVE: In this study,…
PubMed · auteur h-index 138 · 58 citations
Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology. Recently, proposals have attempted to reclassify Lewy body diseases in vivo by merging the long-established clinicopathological entities of Parkinson's disease (P…
Movement Disorders · auteur h-index 220 · 17 citations
Criminal Behavior in Frontotemporal Dementia and Alzheimer Disease. IMPORTANCE: Neurodegenerative diseases can cause dysfunction of neural structures involved in judgment, executive function, emotional processing, sexual behavior, violence,…
JAMA Neurology · auteur h-index 202 · 157 citations
Evaluation of the Cost-effectiveness of Drug Treatment for Alzheimer Disease in a Simulation Model That Includes Caregiver and Societal Factors. Importance: The possibility of widespread use of a novel effective therapy for Alzheimer diseas…
JAMA Network Open · auteur h-index 157 · 35 citations
WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study. As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequen…
Stroke · auteur h-index 155 · 13 citations
Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex. Humans use predictions to improve speech perception, especially in noisy environments. Here we use 7-T functional MR…
Cell Reports · auteur h-index 103 · 26 citations
The science does not yet support regulatory approval of amyloid‐targeting therapies for Alzheimer's disease based solely on biomarker evidence. Amyloid load reduction is an unvalidated surrogate for clinical benefit. Amyloid-targeting antib…
Alzheimer s & Dementia · auteur h-index 123 · 17 citations
Anosognosia in Alzheimer disease: Disconnection between memory and self‐related brain networks. OBJECTIVE: Impaired awareness is a common symptom in many mental disorders including Alzheimer disease (AD). This study aims at improving our un…
Annals of Neurology · auteur h-index 89 · 115 citations
Clinical heterogeneity in familial Alzheimer’s disease. Two studies of non-amnestic manifestations of autosomal dominant familial Alzheimer’s disease (ADAD) are reported in The Lancet Neurology.1Tang M Ryman DC McDade E et al.for the Domina…
The Lancet Neurology · auteur h-index 135 · 24 citations
Prevalence of Comorbidity in Patients With Young-Onset Alzheimer Disease Compared With Late-Onset: A Comparative Cohort Study
Journal of the American Medical Directors Association · auteur h-index 135 · 68 citations
Subjective cognitive decline: Memory complaints, cognitive awareness, and metacognition. Cognitive complaints are common in elderly subjects and are a frequent reason for referral to memory clinics. If the complaints are not associated with…
Alzheimer s & Dementia · auteur h-index 106 · 59 citations
Evolution of anosognosia in alzheimer's disease and its relationship to amyloid. OBJECTIVE: Unawareness, or anosognosia, of memory deficits is a challenging manifestation of Alzheimer's disease (AD) that adversely affects a patient's safety…
Annals of Neurology · auteur h-index 79 · 84 citations
Network Localization of Awareness in Visual and Motor Anosognosia. OBJECTIVE: Unawareness of a deficit, anosognosia, can occur for visual or motor deficits and lends insight into awareness itself; however, lesions associated with anosognosi…
Annals of Neurology · auteur h-index 79 · 30 citations
The olivary input to the cerebellum dissociates sensory events from movement plans. Neurons in the inferior olive are thought to anatomically organize the Purkinje cells (P-cells) of the cerebellum into computational modules, but what is co…
Proceedings of the National Academy of Sciences · auteur h-index 84 · 19 citations
Functional connectivity differences in Alzheimer's disease and amnestic mild cognitive impairment associated with AT(N) classification and anosognosia. ) were established in the 2018 National Institute on Aging and Alzheimer's Association r…
Neurobiology of Aging · auteur h-index 102 · 26 citations
Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. Anosognosia, or loss of insight of memory deficits, is a common and striking symptom in Alzheimer's dise…
NeuroImage Clinical · auteur h-index 172 · 92 citations
Disease awareness in myotonic dystrophy type 1: an observational cross-sectional study. BACKGROUND: Myotonic dystrophy type 1 (Steinert's disease or DM1), the most common form of autosomal dominant muscular dystrophy in adults, is a multisy…
Orphanet Journal of Rare Diseases · auteur h-index 109 · 82 citations
The right occipital lobe and poor insight in first-episode psychosis. Lack of insight is a core feature of non-affective psychosis and has been associated with poorer outcomes. Brain abnormalities underlying lack of insight have been sugges…
PLoS ONE · auteur h-index 136 · 22 citations
The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia
American Journal of Geriatric Psychiatry · auteur h-index 172 · 39 citations
Association of Variation in Behavioral Symptoms With Initial Cognitive Phenotype in Adults With Dementia Confirmed by Neuropathology. IMPORTANCE: Behavioral and psychological symptoms of dementia (BPSDs) in association with amnestic and non…
JAMA Network Open · auteur h-index 99 · 25 citations
Anosognosia for hemiplegia as a tripartite disconnection syndrome. The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored pred…
eLife · auteur h-index 66 · 103 citations
Awareness impairment in Alzheimer’s disease and frontotemporal dementia: a systematic MRI review
Journal of Neurology · auteur h-index 155 · 21 citations
In vivo exploration of synaptic projections in frontotemporal dementia. Abstract The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with…
Scientific Reports · auteur h-index 81 · 25 citations
Metacognition of visuomotor decisions in conversion disorder
Neuropsychologia · auteur h-index 101 · 28 citations
Behavioural and neuroimaging correlates of impaired self-awareness of hypo- and hyperkinesia in Parkinson's disease
Cortex · auteur h-index 134 · 30 citations
Anosognosia in Alzheimer's disease: Diagnosis, frequency, mechanism and clinical correlates
Cortex · auteur h-index 88 · 212 citations
Mentalizing the body: spatial and social cognition in anosognosia for hemiplegia. Following right-hemisphere damage, a specific disorder of motor awareness can occur called anosognosia for hemiplegia, i.e. the denial of motor deficits contr…
Brain · auteur h-index 62 · 64 citations
Mild Cognitive Impairment. PURPOSE OF REVIEW: As individuals age, the quality of cognitive function becomes an increasingly important topic. The concept of mild cognitive impairment (MCI) has evolved over the past 2 decades to represent a s…
CONTINUUM Lifelong Learning in Neurology · auteur h-index 207 · 878 citations
A Web-Based Non-Intrusive Ambient System to Measure and Classify Activities of Daily Living. BACKGROUND: The number of older adults in the global population is increasing. This demographic shift leads to an increasing prevalence of age-asso…
Journal of Medical Internet Research · auteur h-index 61 · 70 citations
Novel Alzheimer’s disease subtypes identified using a data and knowledge driven strategy. The population of adults with Alzheimer's disease (AD) varies in needs and outcomes. The heterogeneity of current AD diagnostic subgroups impedes the…
Scientific Reports · auteur h-index 54 · 42 citations
Aducanumab: What about the Patient?. An enormous controversy has arisen regarding the clinical efficacy and the approval process surrounding aducanumab for the treatment of Alzheimer disease. Moghavem et al accurately recount the chronology…
Annals of Neurology · auteur h-index 207 · 13 citations
A global perspective on dementia care: a Lancet Commission
The Lancet · auteur h-index 98 · 23 citations