Bibliothèque

Oligogenic variants in NEK1 and ATXN2 in amyotrophic lateral sclerosis: report of two cases and review of the literature. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the upper and lower motor neurons and…

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · auteur h-index 147 · 0 citation

No Evidence for Memantine’s Benefit in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-analysis (P10-9.018). To evaluate the efficacy and safety of memantine, an NMDA receptor antagonist, in ALS treatment.

Neurology · auteur h-index 9 · 0 citation

Association between Pre-Disease Plasma Neurofilament Light Polypeptide Biomarker and Amyotrophic Lateral Sclerosis Risk in the Danish Diet, Cancer and Health Study Cohort (LS1.003). To assess plasma neurofilament light polypeptide (NfL) lev…

Neurology · auteur h-index 2 · 0 citation

Bridging the Gap: Three Experimental Proposals for the Physical Substrate of Consciousness. This working paper presents three falsifiable experimental proposals derived from a systematic critical review of consciousness science (companion p…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation

Differentiating Alzheimer’s Disease and Related Dementias Presenting with Isolated Mild Executive-predominant Cognitive Impairment: Role of and Neuropsychological Testing (P4-12.006). To evaluate whether neuropsychological testing in patien…

Neurology · auteur h-index 9 · 0 citation

Efficacy and Safety Results of INFRONT-3: A Phase 3 Randomized, Double-Blind, Placebo Controlled Study Evaluating Latozinemab (AL001) in FTD-GRN (LS2.002). INFRONT-3 is a randomized, double-blind, placebo-controlled phase 3 clinical trial e…

Neurology · auteur h-index 89 · 0 citation

Plasma p-tau as a biomarker for the differential diagnosis of Alzheimer’s disease: a systematic review and meta-analysis. BACKGROUND: With the clinical implementation of amyloid-targeting therapies, accurately differentiating Alzheimer's di…

Alzheimer s Research & Therapy · auteur h-index 14 · 0 citation

Synucleinopathy-like clinical features and biologically defined synuclein seeding in PSP-Parkinsonism: an imperfect match. Whether synucleinopathy-like (syn-like) symptoms match biologically defined synuclein seeding in PSP-parkinsonism (PS…

npj Parkinson s Disease · auteur h-index 76 · 0 citation

AMPK-mediated autophagy induction by bisdemethoxycurcumin attenuates senescence and amyloid pathology in 3xTg-AD mice. Alzheimer disease (AD) pathology is accompanied by increased senescence and reduced levels of autophagy in the brain. We…

Autophagy Reports · auteur h-index 23 · 0 citation

FKBP51 inhibition by SAFit2 modulates tau pathology and cognitive deficits in PS19 mice. The accumulation of pathogenic tau protein is linked to cognitive decline and neuronal loss in Alzheimer's disease (AD), with tau oligomers identified…

Alzheimer s Research & Therapy · auteur h-index 39 · 0 citation

Quantitative LC-MS/MS profiling reveals aberrant chondroitin sulfate in Alzheimer’s disease

UNC Libraries · auteur h-index 88 · 0 citation

Α-Synuclein (α-Syn) and Tau are amyloid proteins involved in neurodegenerative diseases like Parkinson's and Alzheimer's disease, respectively. In healthy cells, both proteins are mainly unfolded and monomeric. However, under pathological c…

Risk of Parkinson disease according to metabolic syndrome: an analysis of data from the National Health Insurance–National Sample Cohort. OBJECTIVES: This study investigated the association of metabolic syndrome (MetS) and its components wi…

Epidemiology and Health · auteur h-index 29 · 0 citation

Hypothalamic MCH neurons links tau pathology to sleep disruption. ABSTRACT Sleep disruption is an early and pervasive feature of Alzheimer’s disease (AD), yet the circuit mechanisms linking tau pathology to sleep-wake dysfunction remain unr…

bioRxiv (Cold Spring Harbor Laboratory) · auteur h-index 40 · 0 citation

Single-cell atlas reveals pathological amplification of aging programs and proteostasis collapse in microglia of Alzheimer′s disease mice. Objective To explore the intrinsic relationship between microglia in Alzheimer′s disease (AD) and nat…

DOAJ (DOAJ: Directory of Open Access Journals) · auteur h-index 0 · 0 citation

NEUROPLASTICITY IN NEURODEGENERATIVE DISEASES : ADAPTATION AMID DECLINE. Introduction: Neuroplasticity, the brain’s intrinsic capacity to reorganize its structure and function, has emerged as a central concept in understanding neurodegenera…

auteur h-index 8 · 0 citation

FDG PET is a powerful adjunct for the differential diagnosis of parkinsonian syndromes because it reveals disease specific regional and network level metabolic signatures. Compared with dopamine transporter imaging, it better distinguishes…

PET Clinics · auteur h-index 89 · 0 citation

Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio. This cross-sectional study evaluates the performance of the US Food and Drug Administration–cleared phosphorylated tau 217 (p-tau217) to…

JAMA Neurology · auteur h-index 28 · 0 citation

Toward a Mathematical Definition of Consciousness. This whitepaper develops and evaluates a mathematically unified candidate framework for consciousness by integrating major theoretical developments from approximately three decades of consc…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation

The CDK4/6 inhibitor abemaciclib attenuates cognitive impairment and neuroinflammation via DYRK1A in human tau transgenic mice. We recently demonstrated that abemaciclib treatment modulates cognitive function, Alzheimer's disease (AD) patho…

Molecular Brain · auteur h-index 0 · 0 citation

Emerging directions in tauopathy research. The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and phil…

Alzheimer s & Dementia · auteur h-index 89 · 0 citation

Rejecting the “formless stuff” response to the origin of consciousness problem for IIT 4.0. This paper examines and ultimately rejects a proposed solution to a problem arising from the ontological commitments of Integrated Information Theor…

Límite · auteur h-index 7 · 0 citation

Report-modulated prefrontal activity and consistent posterior representations during conscious visual perception

Consciousness and Cognition · auteur h-index 20 · 0 citation

Propagation of AI-Generated Misinformation and the Ethical Imperatives for Artificial Intelligence Research: A Critical Synthesis. The rapid advancement of generative artificial intelligence (AI) has reshaped the global information environm…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation

Recursive Compensation and Threshold Crossing in Degenerative Disease. Biological systems maintain functional stability through recursive compensation: when substrate is lost, surviving components absorb redistributed load, preserving appar…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation

The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair. Microglia are critical regulators of neuroinflammation and neurodegeneration. Haploinsufficiency of C9orf72, the most frequently mutated g…

The EMBO Journal · auteur h-index 62 · 0 citation

Cette thèse, intitulée Psychopathologie de la maladie d'Alzheimer : une approche clinique de la mémoire démentielle, prend pour point de départ l'expérience d'une rencontre avec des patients atteints de la maladie d'Alzheimer. Elle cherche…

VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS. During the progression of amyotrophic lateral sclerosis (ALS), only specific motor neurons (MNs) preferentially deteriorate, while oth…

Acta Neuropathologica Communications · auteur h-index 29 · 0 citation

Architectural Variance Dominates Stimulus Variance in Six of Seven Substrate-Agnostic Consciousness Operationalizations. Mathematical theories of consciousness — Integrated Information Theory (IIT), Global Workspace Theory (GWT), Attention…

Open MIND · auteur h-index 1 · 0 citation

Latent Rendering Theory (LRT): Generative Decoding of the Latent Space in Active Inference and the Dynamic Update Architecture of the Self-OS / 潜在レンダリング理論(LRT). Abstract Dreams have historically been interpreted as symbolic messages, mystic…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation

SR104EN: Consciousness, Qualia, and Identity — Formalization of Consciousness in Coherence Cosmology. This paper formalizes consciousness, qualia, identity, and free will on the basis of Coherence Cosmology (SR103). The central claims are a…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 3 · 6 citations

Re-indexing Theories of Consciousness: From Adversarial Comparison to Constraint-Based Harmonization. The scientific study of consciousness is characterized by multiple theoretical frameworks that often appear mutually incompatible. Integra…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 2 · 0 citation

The Hard Problem of Consciousness: Structural Derivation of the Continuing Subject, Formal Proof of Non-Absence, and the Incoherence of Competing Theories. The hard problem of consciousness has not been resolved because it has been posed in…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 2 · 0 citation

Water‐Mediated Phosphoryl Wires Stabilize Pathological Tau Fibrils. ABSTRACT Hyperphosphorylation of tau is a hallmark of tauopathies, with specific phosphorylation sites elevated in pathological fibrils. However, the molecular role of this…

Angewandte Chemie International Edition · auteur h-index 60 · 0 citation

Introspection and Privileged Access. Two senses of privilege are distinguished: “epistemic privilege” indicates that first person claims about mental features are more likely to be knowledge, and “operational privilege” indicates that subje…

auteur h-index 15 · 0 citation

Triptolide Reduces Cholesterol Synthesis and Alleviates Neuroinflammation by Inhibiting CD33 in Alzheimer’s Disease Development and Progression. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, which has recently been f…

Biology · auteur h-index 28 · 0 citation

Reflexive Awareness: The Structural Challenge of Non-Dual Consciousness. Abstract: Reports of awareness without content, ego, or subject-object structure converge across contexts that share neither method nor culture: contemplative traditio…

Zenodo (CERN European Organization for Nuclear Research) · auteur h-index 0 · 0 citation

The microbiota-tryptophan-brain axis in neurodegenerative diseases: pathogenic mechanisms, disease-specific roles, and translational therapeutics. The pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Pa…

Frontiers in Microbiology · auteur h-index 37 · 0 citation

Les Alphaherpesvirus, parmi lesquels le virus Herpes Simplex de type 1 (HSV-1) et le virus Varicelle-Zona (VZV), sont des virus neurotropes humains hautement prévalents dans la population mondiale. Après une primo-infection souvent bénigne,…

Measurement of metacognition of emotional dimensions: a ROC based measurement method for metacognition of valence and arousal. Metacognition of emotions involves accurately assessing one's emotions and the different dimensions of emotions l…

Frontiers in Psychology · 0 citation